Overview
| 别名 | 3-hydroxyisobutyrate dehydrogenase; mitochondrial; HIBADH |
| 基因名 | HIBADH |
| UniProt ID | P31937 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3G9-V1-M3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 35 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | 3-hydroxyisobutyrate dehydrogenase (HIBADH) is a NAD+-dependent oxidoreductase located in the mitochondrial matrix. It catalyzes the reversible oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde, a critical step in the catabolism of the branched-chain amino acid L-valine. As a member of the short-chain dehydrogenase/reductase family, HIBADH is essential for maintaining branched-chain amino acid homeostasis and energy metabolism. Genetic associations suggest a potential link between HIBADH dysfunction and metabolic conditions such as abdominal obesity-metabolic syndrome and renal tubular disorders, implicating it in systemic energy balance regulation. |
检测原理