Overview
| 别名 | Caspase-14; CASP-14) [Cleaved into: Caspase-14 subunit p17; mature form; Caspase-14 subunit p10; mature form; Caspase-14 subunit p20; intermediate form; Caspase-14 subunit p8; intermediate form] |
| 基因名 | Caspase-14 |
| UniProt ID | P31944 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4O2-Y4-B3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 27 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Caspase-14 (CASP14) is a unique member of the caspase family, primarily involved in the regulation of keratinocyte differentiation and the formation of the skin barrier. Unlike other caspases that primarily mediate apoptosis, CASP14 plays a crucial role in a non-apoptotic form of programmed cell death known as cornification, which is essential for the development of the epidermis. The protein is expressed predominantly in the upper layers of the skin, where it is activated through proteolytic cleavage by other caspases, such as caspase-8 and caspase-10. Dysregulation of CASP14 has been implicated in various skin disorders, including atopic dermatitis and other keratinization disorders, where impaired cornification can lead to barrier dysfunction and increased susceptibility to infections. |
检测原理