Overview
| 别名 | Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; CD antigen CD171 |
| 基因名 | L1CAM |
| UniProt ID | P32004 |
| 反应种属 | Human |
| 应用 | WB,IHC-P,ICC/IF |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1O8-X7-R2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 140 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200; IF-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | L1 cell adhesion molecule (L1CAM) is a critical transmembrane glycoprotein involved in neuronal development, promoting cell adhesion, migration, and neurite outgrowth. It consists of six immunoglobulin-like domains and five fibronectin type III domains, facilitating both homophilic and heterophilic interactions essential for neuronal connectivity and myelination processes. L1CAM's dysregulation is implicated in various cancers, including ovarian and gastric cancers, where its overexpression correlates with enhanced cell proliferation, invasion, and metastasis, marking it as a potential biomarker for aggressive tumors. In contrast, mutations in the L1CAM gene lead to L1 syndrome (CRASH), characterized by neurological disorders such as corpus callosum hypoplasia and spastic paraplegia, predominantly affecting males. |
检测原理