Overview
| 别名 | Platelet glycoprotein V; GPV; Glycoprotein 5; CD antigen CD42d |
| 基因名 | GP5 |
| UniProt ID | P40197 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7D8-T2-Y9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 60 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Glycoprotein V platelet (GP5) is a crucial component of the Ib-V-IX complex on platelet surfaces, functioning as a receptor for von Willebrand factor (VWF) and mediating platelet adhesion to injured vascular surfaces in arterial circulation. This 82 kDa membrane-associated protein is part of a heterodimer with alpha (GP1BA) and beta (GP1BB) chains, linked by disulfide bonds. GP5 plays a vital role in hemostasis and platelet activation, with its collagen-binding activity contributing to these processes. Mutations in GP5, along with GP1BA, GP1BB, and GP9, have been associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by abnormal platelet function. Additionally, recent research suggests that GP5 may be involved in regulating epithelial-mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway. |
检测原理