Overview
| 别名 | Thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand |
| 基因名 | THPO |
| UniProt ID | P40225 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7W5-M3-Y7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | The THPO gene encodes thrombopoietin, a cytokine that is essential for the production and maturation of platelets from megakaryocytes in the bone marrow. Thrombopoietin stimulates megakaryocyte proliferation and differentiation, and its levels are inversely regulated by circulating platelets. Biallelic loss-of-function mutations in THPO cause severe thrombocytopenia and bone marrow failure (congenital amegakaryocytic thrombocytopenia-2, CAMT2). In contrast, monoallelic loss-of-function variants lead to reduced thrombopoietin secretion and autosomal-dominant thrombocytopenia without affecting other blood cell lineages. THPO binds to the MPL receptor on megakaryocytes, promoting their maturation and platelet formation. Genetic mutations in the THPO gene can lead to disorders such as essential thrombocythemia and congenital amegakaryocytic thrombocytopenia. |
检测原理