Overview
| 别名 | Protein phosphatase inhibitor 2; IPP-2 |
| 基因名 | PPP1R2 |
| UniProt ID | P41236 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9S3-B6-X5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Protein phosphatase 1 regulatory inhibitor subunit 2 (PPP1R2), plays a crucial role in regulating protein phosphatase 1 (PP1), a key enzyme involved in various cellular processes, including glycogen metabolism and cell division. This protein, which is expressed in multiple tissues, functions primarily as an inhibitor of PP1 by stabilizing specific holoenzyme complexes, thus modulating the dephosphorylation of substrates. Its regulatory activity is complex; while it can inhibit PP1's function by occluding the active site, it also promotes the stability of certain PP1 complexes, enhancing their activity under specific conditions. Dysregulation of PPP1R2 has been implicated in several diseases, including cancer, where it may contribute to abnormal cell division and proliferation. |
检测原理