Overview
| 别名 | Tyrosine-protein kinase Tec |
| 基因名 | TEC |
| UniProt ID | P42680 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 6C1-J3-N5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 73 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Tec protein tyrosine kinase (TEC) is a non-receptor tyrosine kinase and the founding member of the Tec family. It is primarily expressed in hematopoietic cells, where it integrates signals from antigen receptors, cytokine receptors, and integrins to regulate calcium signaling, gene transcription, and cell survival. Structurally, TEC contains PH, TH, SH3, and SH2 domains that facilitate its recruitment to the plasma membrane via PI3K-generated PIP3. It plays a critical role in T-cell and B-cell activation, as well as platelet signaling. Clinically, altered TEC activity is linked to immune dysregulation and chronic inflammation. Additionally, TEC exhibits cardioprotective roles during ischemic heart injury through its interactions with HIF-1α and ROCK1, highlighting its importance in stress-activated signaling pathways. |
检测原理