Overview
| 别名 | Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 |
| 基因名 | SLC1A4 |
| UniProt ID | P43007 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2G1-J5-Y7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 55 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Solute carrier family 1 member 4 (SLC1A4) is a sodium-dependent neutral amino acid transporter that mediates the uptake of alanine, serine, cysteine, and threonine. Widely expressed in the brain, lungs, and kidneys, it plays a critical role in maintaining amino acid homeostasis and regulating neurotransmitter levels. In the central nervous system, SLC1A4 facilitates the efflux of L-serine and glutamate from neurons into the synaptic junction. Mutations in the SLC1A4 gene are the primary cause of spastic tetraplegia with thin corpus callosum and progressive microcephaly (SPATCCM), an autosomal recessive neurodevelopmental disorder. This clinical association underscores the transporter's essential role in brain development and neurological function, making it a key target for research into intellectual disability and developmental delay. |
检测原理