Overview
| 别名 | Glycerol-3-phosphate dehydrogenase; mitochondrial; GPD-M; GPDH-M; mitohondrial glycerophosphate dehydrogenase gene; mGDH; mtGPD |
| 基因名 | GPD2 |
| UniProt ID | P43304 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1Q8-F6-M3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 80 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Glycerol-3-phosphate dehydrogenase 2 (GPD2) is a flavoprotein dehydrogenase located on the inner mitochondrial membrane that serves as the mitochondrial component of the glycerol phosphate shuttle. It catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate while simultaneously reducing ubiquinone, thereby linking cytosolic NADH metabolism to the mitochondrial respiratory chain. GPD2 is essential for triglyceride metabolism, glycerophospholipid biosynthesis, and maintaining mitochondrial redox balance. Clinically, GPD2 dysfunction is associated with type 2 diabetes mellitus, where altered energy metabolism in beta-cells contributes to disease pathogenesis. In diabetic kidney disease, GPD2 deficiency exacerbates podocyte injury. Additionally, GPD2-generated ubiquinol has been shown to suppress lipid peroxidation, providing a defense mechanism against ferroptosis in various cancer types. |
检测原理