Overview
| 别名 | Killer cell immunoglobulin-like receptor 3DL1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD antigen CD158e |
| 基因名 | KIR3DL1 |
| UniProt ID | P43629 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3C6-A3-X8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) is a member of the KIR family of receptors, which are expressed on natural killer (NK) cells and some T cells. This receptor is characterized by its ability to recognize specific human leukocyte antigen (HLA) class I molecules, particularly those expressing the Bw4 epitope of HLA-A and HLA-B. KIR3DL1 plays a critical role in regulating NK cell activity, providing inhibitory signals that prevent the destruction of healthy cells while allowing for the targeting of infected or malignant cells. Dysregulation or altered expression of KIR3DL1 has been associated with several conditions, including viral infections such as HIV, where certain alleles may confer protection or increased susceptibility. Additionally, its interaction with HLA molecules is implicated in the outcomes of organ transplantation and autoimmune diseases. |
检测原理