Overview
| 别名 | Transcriptional regulator ATRX; ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein; XNP; Znf-HX |
| 基因名 | ATRX |
| UniProt ID | P46100 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1D1-S4-Z4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 282 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | ATRX chromatin remodeler (ATRX) is a critical protein involved in regulating gene expression through the modification of chromatin structure. It functions by altering DNA packaging to modulate the activity of target genes, most notably the alpha-globin genes HBA1 and HBA2. ATRX also plays a vital role in stabilizing G-rich DNA regions by remodeling G-quadruplexes and facilitating the incorporation of H3.3-containing nucleosomes. It is typically localized to PML bodies within the nucleus. Mutations in the ATRX gene are the cause of alpha thalassemia X-linked intellectual disability syndrome. Furthermore, somatic mutations in ATRX are frequently observed in myelodysplastic syndrome (MDS) and can lead to the development of alpha thalassemia myelodysplastic syndrome (ATMDS) as the disease progresses. |
检测原理