Overview
| 别名 | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-Phosphate 4-Kinase; PI5P4Kalpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha |
| 基因名 | PIP4K2A |
| UniProt ID | P48426 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6Q9-E9-C6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 46 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K2A) is a lipid kinase that phosphorylates phosphatidylinositol-5-phosphate (PtdIns5P) to generate phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2]. By modulating these phosphoinositide pools, it regulates PI3K-AKT signaling, vesicle trafficking, and autophagy during nutrient stress. PIP4K2A also influences ciliogenesis by phosphorylating macrophage migration inhibitory factor (MIF). Clinically, PIP4K2A exhibits context-dependent roles in cancer; it acts as a tumor suppressor in PTEN-deficient glioblastoma by attenuating AKT signaling, whereas it is required for the maintenance of leukemia-initiating cells in acute myeloid leukemia. Its loss in leukemic contexts triggers cell-cycle arrest, highlighting its potential as a therapeutic target in specific hematological malignancies. |
检测原理