Overview
| 别名 | Mannan-binding lectin serine protease 1; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain] |
| 基因名 | MASP1 |
| UniProt ID | P48740 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9K4-N3-U3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 79 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | MBL associated serine protease 1 (MASP1) is a modular serine protease that plays a central role in the lectin pathway of the complement system, a key component of innate immunity responsible for recognizing and eliminating pathogens through carbohydrate pattern recognition. Structurally, MASP1 belongs to the C1r/C1s/MASP family and features a serine protease domain that is evolutionarily distinct, with a substrate-binding groove resembling that of trypsin, which accounts for its relatively broad substrate specificity. Unique structural elements, such as an unusually large 60-loop and an internal salt bridge between Asp189 and Arg224, modulate its activity and restrict its specificity compared to trypsin, ensuring controlled proteolytic function in blood. MASP1 is multifunctional, acting not only in complement activation but also cleaving non-complement substrates like fibrinogen and factor XIII, linking it to coagulation processes. Clinically, MASP1 gene variants have been associated with altered protein function, and deficiencies or mutations can influence susceptibility to infections and may contribute to rare developmental disorders. |
检测原理