Overview
| 别名 | Ras association domain-containing protein 2 |
| 基因名 | RASSF2 |
| UniProt ID | P50749 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3X8-F6-X7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ras association domain family member 2 (RASSF2) is a potential tumor suppressor protein containing a Ras association domain. It functions as a KRAS-specific effector, promoting apoptosis and cell cycle arrest. RASSF2 interacts with K-Ras in a GTP-dependent manner and forms a complex with the prostate apoptosis response protein 4 (PAR-4) tumor suppressor. It plays a role in regulating PAR-4 nuclear translocation, which is essential for its apoptotic function. RASSF2 is primarily localized in the nucleus and is involved in protein stabilization and regulation of intracellular signal transduction. The gene is frequently epigenetically inactivated in various cancers, particularly in prostate cancer. Loss of RASSF2 expression enhances K-Ras-induced transformation and confers resistance to TRAIL-induced cell death in prostate cancer cells. RASSF2 inactivation is implicated in the early stages of colorectal tumorigenesis and may contribute to the development of other cancers. |
检测原理