Overview
| 别名 | Spermine synthase; SPMSY; Spermidine aminopropyltransferase |
| 基因名 | SMS |
| UniProt ID | P52788 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3G9-Q2-E1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 41 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Spermine synthase (SMS) is a cytosolic aminopropyltransferase that catalyzes the conversion of spermidine to spermine, utilizing decarboxylated S-adenosylmethionine as a donor. This reaction is critical for maintaining intracellular polyamine homeostasis, which is essential for normal cell growth and viability. Structurally, SMS functions as a homodimer, with each subunit containing a catalytic domain that exhibits high specificity for its substrates. The SMS gene is located on the X chromosome. Loss-of-function or missense mutations in SMS cause Snyder-Robinson syndrome, an X-linked intellectual disability disorder. This condition is characterized by intellectual impairment, marfanoid habitus, osteoporosis, and hypotonia. The resulting deficiency in spermine and accumulation of spermidine lead to significant developmental and neurological abnormalities. |
检测原理