Overview
| 别名 | Clathrin heavy chain 2; Clathrin heavy chain on chromosome 22; CLH-22 |
| 基因名 | CLTCL1 |
| UniProt ID | P53675 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 2C7-B2-Y4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 187 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Clathrin Heavy Chain Like 1 (CLTCL1), encoded by the CLTCL1 gene, is a protein homologous to the clathrin heavy chain (CLTC) and plays a role in clathrin-mediated intracellular trafficking. Structurally, CLTCL1 contains a terminal globular domain for cargo binding, a proximal helical tripod for triskelion assembly, and a C-terminal light-chain-binding motif. Unlike CLTC, CLTCL1 is primarily expressed in the brain, testis, and skeletal muscle, and it forms distinct clathrin lattices, influencing vesicle formation during endocytosis, organelle biogenesis, and receptor recycling. CLTCL1 also interacts with adaptor proteins like AP-1 and NECAP1, modulating synaptic vesicle recycling and Golgi-lysosomal trafficking. CLTCL1 mutations are linked to rare neurodevelopmental disorders and myopathies. For instance, homozygous loss-of-function variants are associated with severe infantile encephalopathy, hypotonia, and developmental delay. Additionally, dysregulated CLTCL1 expression is implicated in Alzheimer’s disease pathology, potentially affecting amyloid precursor protein trafficking. |
检测原理