Overview
| 别名 | Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] |
| 基因名 | ITGA8 |
| UniProt ID | P53708 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4I6-T3-Z3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 117 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Integrin subunit alpha 8 (ITGA8) is a type I transmembrane protein that dimerizes with the beta1 subunit to form the alpha8beta1 integrin receptor. This receptor recognizes RGD motifs in extracellular matrix ligands such as fibronectin, tenascin, and nephronectin, mediating cell adhesion, cytoskeletal reorganization, and mesenchymal-to-epithelial transitions. ITGA8 is vital for organogenesis, particularly during kidney development, where it facilitates ureteric bud branching and metanephric mesenchyme condensation. Clinically, mutations in the ITGA8 gene are the cause of renal hypodysplasia/aplasia-1 (RHDA1), a severe condition characterized by bilateral renal agenesis or hypoplasia. Its critical role in nephrogenesis makes it a significant marker for understanding congenital anomalies of the kidney and urinary tract. |
检测原理