Overview
| 别名 | Ataxin-1; Spinocerebellar ataxia type 1 protein |
| 基因名 | ATXN1 |
| UniProt ID | P54253 |
| 反应种属 | Human,Mouse |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8Z8-V7-I9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 86 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ataxin-1 (ATXN1) is a nuclear protein encoded by the ATXN1 gene, primarily known for its role in the regulation of gene expression and RNA processing. It contains an AXH domain, which facilitates interactions with other proteins, thereby influencing various cellular functions. ATXN1 is widely expressed in the brain and other tissues, where it participates in transcriptional regulation and may be involved in the assembly of protein complexes that modulate gene activity. The protein's structure allows it to engage in dynamic interactions within the nucleus, impacting cellular signaling pathways. Notably, mutations in the ATXN1 gene can lead to spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder characterized by motor coordination issues due to protein misfolding and aggregation. |
检测原理