Overview
| 别名 | Adenosine kinase; AK; Adenosine 5'-phosphotransferase |
| 基因名 | ADK |
| UniProt ID | P55263 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1Z3-X8-L2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Adenosine kinase (ADK) is a cytoplasmic and nuclear enzyme critical for adenosine homeostasis, catalyzing the phosphorylation of adenosine to adenosine monophosphate (AMP) using ATP. This reaction regulates extracellular adenosine levels, influencing purine metabolism, DNA methylation, and adenosine receptor signaling. ADK exists in two isoforms: ADK-long (ADK-L), predominantly nuclear and associated with transcriptional regulation, and ADK-short (ADK-S), cytoplasmic and involved in metabolic clearance of adenosine. The enzyme’s activity is pivotal in maintaining cellular energy balance and modulating neuroprotective, anti-inflammatory, and anticonvulsant adenosine-mediated pathways. ADK dysfunction is linked to hypermethioninemia, a metabolic disorder characterized by elevated methionine due to impaired S-adenosylhomocysteine hydrolysis. Additionally, ADK overexpression in epilepsy reduces adenosine’s anticonvulsant effects. ADK deficiency may also contribute to liver disease and developmental abnormalities. |
检测原理