Overview
| 别名 | Cadherin-6; Kidney cadherin; K-cadherin |
| 基因名 | K-Cadherin |
| UniProt ID | P55285 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8U6-B2-A4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 88 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cadherin 6 (K-Cadherin) is a type II calcium-dependent cell adhesion molecule that mediates homophilic interactions to maintain tissue structural integrity and facilitate cell sorting. As a membrane glycoprotein, it localizes to endometrial luminal epithelial cells and plays essential roles in kidney development, placental formation, and the organization of cell-cell junctions. Functionally, it participates in the ERK signaling pathway and is critical for maintaining the integrity of reproductive tissues. Pathologically, mutations in the CDH6 gene are linked to craniofacial-deafness-hand syndrome and renal cell carcinoma, while decreased expression levels are associated with tumor growth and metastasis in various malignancies. Additionally, knockdown of CDH6 in endometrial epithelial cells compromises cell integrity, highlighting its importance in reproductive tissue function. |
检测原理