Overview
| 别名 | Forkhead box protein L2 |
| 基因名 | FOXL2 |
| UniProt ID | P58012 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6T3-Y7-Z6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 38 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Forkhead box L2 (FOXL2) is a forkhead family transcription factor that plays a central role in female sex determination and ovarian development. It is expressed in the eyelids, pituitary, and ovarian granulosa cells, where it regulates genes involved in steroidogenesis, such as CYP19, and represses testis-determining programs by inhibiting SOX9. FOXL2 is essential for maintaining granulosa cell identity and regulating proliferation and apoptosis. Clinically, germline mutations in FOXL2 cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), which is frequently associated with primary ovarian insufficiency. Additionally, the somatic C134W mutation in FOXL2 is a pathognomonic marker for adult granulosa cell tumors, where it disrupts normal cell cycle control to promote tumorigenesis. |
检测原理