Overview
| 别名 | Proteasome subunit alpha type-6; 27 kDa prosomal protein; PROS-27; p27K; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chain; Proteasome subunit alpha-1; alpha-1 |
| 基因名 | PSMA6 |
| UniProt ID | P60900 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5X7-F3-E1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 27 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proteasome 20S subunit alpha 6 (PSMA6) is a 27 kDa protein composed of 246 amino acids and encoded by the PSMA6 gene located at chromosome 14q13. As one of the seven alpha subunits forming the outer rings of the barrel-shaped 20S proteasome core, PSMA6 is essential for the assembly and function of the proteasome complex, which is responsible for the ATP/ubiquitin-dependent degradation of most intracellular proteins, maintaining protein homeostasis by removing misfolded, damaged, or regulatory proteins. The 20S core can associate with regulatory particles such as 19S, PA200, or PA28, enabling both ubiquitin-dependent and -independent proteolysis, which is crucial in processes like antigen presentation and spermatogenesis. Clinically, PSMA6 expression is upregulated in certain diseases, including breast cancer and viral hepatitis, suggesting a role in disease progression and immune regulation, with higher expression observed in tumor tissues compared to normal tissues. |
检测原理