Overview
| 别名 | Fibroblast growth factor 12; FGF-12; Fibroblast growth factor homologous factor 1; FHF-1; Myocyte-activating factor |
| 基因名 | FGF12 |
| UniProt ID | P61328 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2T2-X5-J5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 27 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Fibroblast growth factor 12 (FGF12), also known as FGF homologous factor 1B, is an intracellular, non-secreted member of the FGF homologous factors subfamily that lacks a classical signal peptide and heparin-binding capacity, distinguishing it from canonical paracrine FGFs. FGF12 is predominantly expressed in the nervous system, where it binds and modulates voltage-gated sodium channels (Nav1.x), positively regulating their activity and thereby influencing neuronal excitability and action potential firing. It localizes mainly to the cytoplasm and nucleus and does not activate classical FGF receptors, instead acting as an intracellular modulator of ion channel function. Disease relevance centers on cardiac arrhythmia and neuro-excitability phenotypes: FGF12 variants or altered expression have been associated with inherited arrhythmia syndromes and abnormal cardiac conduction, as well as potential roles in epilepsy and other channelopathy-related disorders, consistent with its critical regulatory role in excitable tissues. |
检测原理