Overview
| 别名 | Ubiquitin-fold modifier 1 |
| 基因名 | UFM1 |
| UniProt ID | P61960 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6Z2-N5-C1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 9 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein that plays a crucial role in various cellular processes through a post-translational modification known as UFMylation. This process involves the covalent attachment of UFM1 to lysine residues on target proteins, similar to ubiquitination. UFM1 is essential for maintaining cellular homeostasis, particularly in the endoplasmic reticulum (ER), where it regulates ER-associated degradation, ribosome quality control, and responses to stress. Mutations in genes associated with the UFM1 system, such as UFM1 itself, UBA5, and UFC1, have been linked to severe human diseases, including hereditary developmental epileptic encephalopathy and Schohat-type osteochondrodysplasia. These conditions underscore the importance of UFM1 in developmental processes and highlight its potential as a therapeutic target in diseases related to protein misfolding and stress responses in cells. |
检测原理