Overview
| 别名 | SRSF protein kinase 2; SFRS protein kinase 2; Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] |
| 基因名 | SRPK2 |
| UniProt ID | P78362 |
| 反应种属 | Human |
| 应用 | WB,IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 4F8-F2-A3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 77 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SRSF protein kinase 2 (SRPK2) is a serine/arginine-rich protein kinase that plays a critical role in pre-mRNA splicing by phosphorylating serine/arginine (SR) proteins, which are essential for spliceosome assembly and function. SRPK2 is highly expressed in the brain and is involved in the regulation of alternative splicing, influencing various cellular processes such as cell proliferation, differentiation, and apoptosis. It has been shown to interact with several signaling pathways, including the mTORC1 pathway, which regulates lipid metabolism and affects cancer cell growth. Dysregulation of SRPK2 has been implicated in various diseases, particularly cancer; its overexpression has been associated with poor prognosis in melanoma and other malignancies due to its role in promoting cell migration and invasion. |
检测原理