Overview
| 别名 | Butyrophilin subfamily 3 member A2 |
| 基因名 | BTN3A2 |
| UniProt ID | P78410 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1Z2-Y7-J9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 36 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Butyrophilin subfamily 3 member A2 (BTN3A2) is a type I transmembrane protein encoded by the BTN3A2 gene located on chromosome 6. It plays a significant role in the immune system, particularly in the activation of Vγ9Vδ2 T cells, which are crucial for immune responses against infections and tumors. BTN3A2 lacks the B30.2 domain found in other butyrophilins but contains one V-type immunoglobulin-like domain, contributing to its function in immune modulation. Elevated expression of BTN3A2 has been associated with various diseases, including Systemic Lupus Erythematosus and ovarian cancer, where it may enhance immune co-stimulation and influence T-cell proliferation and cytokine production. The protein's structure allows it to interact with specific antibodies, further elucidating its role in immune signaling pathways. |
检测原理