Overview
| 别名 | Disabled homolog 2; Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; DOC-2; Differentially-expressed protein 2 |
| 基因名 | DAB2 |
| UniProt ID | P98082 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8K7-S6-L9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 82 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DAB adaptor protein 2 (DAB2), also known as Disabled-2, is a cytosolic clathrin-associated sorting protein (CLASP) essential for clathrin-mediated endocytosis. It utilizes an N-terminal PTB domain to bind cargo, including the LDL receptor and integrins, linking them to the endocytic machinery via interactions with AP-2 and myosin VI. Beyond trafficking, DAB2 modulates signaling pathways such as TGF-beta and Wnt, and regulates platelet integrin function. Frequently downregulated in epithelial cancers, DAB2 functions as a putative tumor suppressor, maintaining cell polarity and inhibiting unconstrained growth. |
检测原理