Overview
| 别名 | 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-2; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2 |
| 基因名 | PLCB2 |
| UniProt ID | Q00722 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1C2-Z3-B3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 134 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Phospholipase C beta 2 (PLCB2) is a calcium-dependent phosphodiesterase that plays a central role in intracellular signal transduction. It catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into two secondary messengers: inositol 1,4,5-trisphosphate (IP3), which triggers calcium release, and diacylglycerol (DAG), which activates protein kinase C. PLCB2 is specifically activated by G-protein alpha-q and beta-gamma subunits, making it a key effector in pathways such as taste receptor signaling, platelet activation, and neutrophil immune responses. It also interacts with regulatory proteins like MAP2K3 and TRPM7 to coordinate cellular movement and inflammatory signaling. Clinically, mutations in PLCB2 are associated with familial hepatic adenomas and Charcot-Marie-Tooth disease, dominant intermediate F, reflecting its critical requirement in both metabolic regulation and the maintenance of peripheral nerve function. |
检测原理