Overview
| 别名 | CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83 |
| 基因名 | CD83 |
| UniProt ID | Q01151 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7B2-J8-Y8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CD83 is a member of the immunoglobulin superfamily that plays a crucial role in regulating immune responses. It is expressed on the surface of various activated immune cells, including dendritic cells, B cells, T cells, and macrophages. CD83 exists in both membrane-bound and soluble forms, with the soluble form potentially having immunosuppressive functions. Interestingly, CD83 is not a typical co-stimulatory molecule but rather acts as an immune checkpoint, controlling and resolving immune responses. It is essential for the differentiation of T and B cells and the development and maintenance of immune tolerance. CD83 has been identified as a promising therapeutic target, with preclinical studies demonstrating its immunomodulatory potential in various disease models. |
检测原理