Overview
| 别名 | Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase; receptor-related 2 |
| 基因名 | ROR2 |
| UniProt ID | Q01974 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7L5-E9-D4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 104 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Receptor tyrosine kinase like orphan receptor 2 (ROR2) is a transmembrane protein that mediates noncanonical WNT5A signaling to orchestrate tissue morphogenesis. It features extracellular cysteine-rich (CRD) and Kringle domains, with the CRD facilitating a novel lipid-independent mechanism for ligand reception. ROR2 is essential for the development of cartilage and the growth plate, playing a pivotal role in skeletal formation. It acts by potentiating receptor super-complexes, including Frizzled, to transduce signals necessary for proper bone growth. Mutations in the ROR2 gene are well-established causes of Robinow syndrome, characterized by skeletal abnormalities, and autosomal dominant brachydactyly type B, which affects digit development. These clinical associations underscore the protein's fundamental importance in skeletal morphogenesis and developmental signaling. |
检测原理