Overview
| 别名 | Desmocollin-2; Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III |
| 基因名 | DSC2 |
| UniProt ID | Q02487 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6B2-P8-J8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 99 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Desmocollin 2 (DSC2) is a calcium-dependent glycoprotein and a member of the cadherin superfamily, primarily functioning as a key component of desmosomes—specialized cell-cell junctions that provide mechanical strength and stability to tissues by linking adjacent cells together. Structurally, DSC2 contains five N-terminal extracellular domains, a transmembrane domain, and a C-terminal cytoplasmic tail, enabling it to interact with desmoglein family members and plakoglobin, and it undergoes posttranslational modifications such as N-glycosylation and O-mannosylation. DSC2 is ubiquitously expressed in desmosomal tissues like skin epithelia and is the only desmocollin isoform present in cardiac muscle, where it localizes to intercalated discs and is essential for maintaining cardiac tissue integrity. Mutations in the DSC2 gene disrupt desmosome structure and function, leading to impaired cell adhesion and are causally linked to arrhythmogenic right ventricular cardiomyopathy and other disorders affecting the heart, skin, and hair. |
检测原理