Overview
| 别名 | DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme |
| 基因名 | TOP2B |
| UniProt ID | Q02880 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5S7-O6-U5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 183 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which alleviates torsional stress generated during these processes. TOP2B is characterized by its ability to bind ATP and catalyze the cleavage and religation of DNA strands, thus maintaining genomic integrity. Unlike its paralog TOP2A, TOP2B is expressed in both dividing and non-dividing cells and is essential for various cellular functions, including neuronal activity and gene regulation. Dysregulation of TOP2B has been implicated in several diseases, particularly cancer, where its activity can contribute to chromosomal translocations and mutations. Additionally, alterations in TOP2B expression have been linked to neurodevelopmental disorders and other conditions. |
检测原理