Overview
| 别名 | Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase |
| 基因名 | ACY1 |
| UniProt ID | Q03154 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2F6-E3-F4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 45 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IHC-1:100-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Aminoacylase 1 (ACY1) is a crucial cytosolic enzyme that catalyzes the hydrolysis of N-acylated L-amino acids into free L-amino acids and acyl groups, playing a significant role in amino acid metabolism and recycling. This homodimeric, zinc-binding enzyme is predominantly expressed in various tissues, including the kidneys and brain, and is essential for the catabolism of acylated amino acids, which are vital for protein synthesis and cellular function. Mutations in the ACY1 gene can lead to aminoacylase 1 deficiency (ACY1D), an extremely rare autosomal recessive metabolic disorder characterized by neurological impairments such as developmental delays, intellectual disability, and increased urinary excretion of N-acetylated amino acids. Overall, ACY1 is integral to maintaining amino acid homeostasis and its dysfunction has significant implications for neurological health. |
检测原理