Overview
| 别名 | Golgin subfamily A member 3; Golgi complex-associated protein of 170 kDa; GCP170; Golgin-160 |
| 基因名 | GOLGA3 |
| UniProt ID | Q08378 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4W8-V9-F4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 167 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Golgin A3 (GOLGA3) is a coiled-coil protein localized to the Golgi apparatus that functions as a member of the golgin family of auto-antigens. It plays a central role in maintaining the structural integrity of the Golgi stack and facilitating microtubule interactions required for post-mitotic Golgi reorganization. GOLGA3 is ubiquitously expressed across various tissues, including the liver, testis, and lungs, where it exhibits a granular cytoplasmic distribution. Beyond its structural roles, it is involved in nuclear transport and Rho GTPase signaling pathways. Clinically, GOLGA3 is associated with Primary Ciliary Dyskinesia, a genetic disorder characterized by impaired motile cilia function. This leads to chronic respiratory infections, infertility, and situs inversus. Its role as a Golgi scaffold is essential for the proper trafficking and localization of proteins necessary for ciliary assembly and cellular homeostasis. |
检测原理