Overview
| 别名 | Testican-1; Protein SPOCK |
| 基因名 | SPOCK1 |
| UniProt ID | Q08629 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5E3-M8-W4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1) is a multidomain proteoglycan belonging to the SPARC family, consisting of an N-terminus, follistatin-like domain, extracellular calcium-binding domain, and a C-terminus with thyropin and Kazal-like domains. It contains both heparan and chondroitin sulfate chains, distinguishing it from SPOCK2 and SPOCK3. SPOCK1 is widely expressed in tissues including brain, cartilage, and vascular endothelium, playing roles in cell-cell and cell-matrix interactions, extracellular matrix regulation, and neurodevelopment. The protein is involved in various cellular processes such as adhesion, proliferation, and apoptosis. In pathological conditions, SPOCK1 has been implicated in cancer progression, particularly in promoting epithelial-mesenchymal transition, invasion, and metastasis through activation of signaling pathways like PI3K/Akt and Wnt/β-catenin. Overexpression of SPOCK1 is associated with poor clinical outcomes in several cancer types. |
检测原理