Overview
| 别名 | Protein flightless-1 homolog |
| 基因名 | FLII |
| UniProt ID | Q13045 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 7X4-V5-B2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 144 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | FLII actin remodeling protein (FLII) is a multifunctional actin-remodeling protein of the gelsolin family, featuring an N-terminal leucine-rich repeat (LRR) domain and C-terminal gelsolin-like domains. It functions as an actin-capping and polymerization-inhibiting factor, regulating filament length and focal adhesion dynamics without severing actin. Beyond the cytoskeleton, FLII acts as a transcriptional coactivator and signaling scaffold, integrating cytoskeletal remodeling with nuclear receptor signaling. FLII is recognized as a negative regulator of wound repair; its elevated expression impairs re-epithelialization and collagen remodeling, while its inhibition improves healing outcomes, making it a potential therapeutic target for chronic wounds and fibrosis. |
检测原理