Overview
| 别名 | Zinc finger and BTB domain-containing protein 17; Myc-interacting zinc finger protein 1; Miz-1; Zinc finger protein 151; Zinc finger protein 60 |
| 基因名 | ZBTB17 |
| UniProt ID | Q13105 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3V8-K9-L1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 87 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Zinc finger and BTB domain-containing protein 17 (ZBTB17), also known as Miz-1, is a transcription factor characterized by its BTB/POZ domain and multiple zinc finger motifs, which facilitate its role in DNA binding and protein-protein interactions. ZBTB17 is involved in regulating gene expression during various biological processes, including lymphocyte development and cell cycle progression. It plays a crucial role in T cell differentiation by modulating IL-7 signaling and influencing the expression of genes associated with lymphopoiesis. Dysregulation of ZBTB17 has been linked to several diseases, particularly immune disorders and cancers. For instance, mutations or altered expression of ZBTB17 can lead to impaired T cell development, contributing to autoimmune diseases. Additionally, its role in regulating oncogenes suggests that ZBTB17 may act as a tumor suppressor; thus, its loss of function is associated with the progression of certain malignancies. |
检测原理