Overview
| 别名 | Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4 |
| 基因名 | BIK |
| UniProt ID | Q13323 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9Z5-D4-P9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 18 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Bcl-2-interacting killer (BIK) is a pro-apoptotic protein and a member of the BH3-only subfamily of Bcl-2 proteins, which are critical regulators of apoptosis. Encoded by the BIK gene, this protein is primarily localized in the endoplasmic reticulum and plays a crucial role in promoting cell death by interacting with anti-apoptotic proteins such as Bcl-2 and Bcl-xL, thereby facilitating the release of cytochrome c from mitochondria and activating downstream caspases. Dysregulation of BIK has been implicated in various diseases, particularly cancers, where its expression is often suppressed due to chromosomal deletions or epigenetic modifications. In tumors, reduced BIK levels can lead to increased cell survival and resistance to chemotherapy. |
检测原理