Overview
| 别名 | Receptor-type tyrosine-protein phosphatase S; R-PTP-S; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma |
| 基因名 | PTPRS |
| UniProt ID | Q13332 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9Q5-M2-J3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 217 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Protein tyrosine phosphatase receptor type S (PTPRS), also known as PTPσ, is a receptor-type protein phosphatase primarily expressed in the central nervous system. It plays a crucial role in regulating various cellular processes, including synaptic plasticity and neuronal differentiation, by modulating signaling pathways through dephosphorylation of tyrosine residues on target proteins. PTPRS is characterized by its extracellular immunoglobulin-like domains and intracellular phosphatase domains, which include an active catalytic site and a regulatory domain. This protein has been implicated in several diseases, particularly Alzheimer's disease, where its genetic variants are associated with neuroprotection against early tau pathology and synaptic degeneration. Additionally, PTPRS has been linked to cholangiocarcinoma, where its expression levels correlate with patient survival outcomes. |
检测原理