Overview
| 别名 | Frizzled-5; Fz-5; hFz5; FzE5 |
| 基因名 | FZD5 |
| UniProt ID | Q13467 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 4R8-Q7-O3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 64 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Frizzled class receptor 5 (FZD5) is a seven-transmembrane G protein-coupled receptor that serves as a primary mediator of Wnt signaling. It features an N-terminal cysteine-rich domain that forms a hydrophobic groove essential for ligand recognition. FZD5 exhibits dual specificity, binding both canonical ligands like Wnt7a to activate the beta-catenin pathway and non-canonical ligands like Wnt5a to trigger classical GPCR signaling through Galphaq and second messengers. These pathways are critical for embryonic development, stem cell regulation, and adult tissue homeostasis. The receptor's structural flexibility allows it to integrate diverse extracellular signals to control cellular fate and architecture. Clinically, dysregulation of FZD5 is significantly implicated in cancer biology, particularly in ovarian cancer, where it contributes to chemoresistance through the modulation of aldehyde dehydrogenase 1A1 expression, making it a relevant target for overcoming drug resistance in oncology. |
检测原理