Overview
| 别名 | GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 |
| 基因名 | GAB1 |
| UniProt ID | Q13480 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6T3-I1-X6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 76 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | GRB2 associated binding protein 1 (GAB1) is a critical adapter protein belonging to the IRS1-like multisubstrate docking family. It plays a central role in diversifying and amplifying intracellular signaling downstream of various receptor tyrosine kinases, including EGFR, FGFR1, and the insulin receptor. GAB1 is particularly essential for mediating signals from the MET/HGF receptor, where it facilitates the recruitment of key effectors such as PI3K, Grb2, and Src through its SH2 and SH3 domains. These interactions are vital for complex cellular processes such as branching tubulogenesis, epithelial morphogenesis, and hepatocyte proliferation. By acting as a scaffold, GAB1 coordinates pathways that govern cellular growth, transformation, and anti-apoptotic responses, making it a fundamental component of the signaling networks that regulate tissue development and repair. |
检测原理