Overview
| 别名 | Baculoviral IAP repeat-containing protein 2; Cellular inhibitor of apoptosis 1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; hIAP-2; hIAP2; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2 |
| 基因名 | BIRC2 |
| UniProt ID | Q13490 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA,IP-MS |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9F9-K4-L8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 69 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Baculoviral IAP repeat-containing protein 2 (BIRC2), also known as c-IAP1, is a member of the inhibitor of apoptosis (IAP) family, characterized by the presence of multiple baculoviral IAP repeats (BIR) and a RING finger domain. BIRC2 functions primarily as an E3 ubiquitin ligase, playing a critical role in regulating apoptosis by inhibiting caspase activation and promoting cell survival. It is involved in various cellular processes, including cell proliferation, inflammation, and immune responses. Dysregulation of BIRC2 has been implicated in several diseases, particularly cancer; its overexpression is often associated with tumorigenesis and resistance to chemotherapy in various malignancies, including colorectal and breast cancers. Additionally, BIRC2 has been linked to autoimmune diseases, where its regulatory effects on apoptosis can contribute to the survival of autoreactive lymphocytes. |
检测原理