Overview
| 别名 | Mastermind-like domain-containing protein 1; F18; Protein CG1 |
| 基因名 | MAMLD1 |
| UniProt ID | Q13495 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6V2-O4-K5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 83 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Mastermind-like domain-containing protein 1 (MAMLD1) is a transcriptional co-activator involved in the regulation of DNA-dependent transcription and male gonad development. It exists in multiple isoforms approximately 80-106 kDa in size and plays a role in transactivating the HES3 promoter independently of canonical NOTCH signaling pathways. MAMLD1 is linked to the Notch-HLH transcription pathway and is a key factor in male sex differentiation. Structurally, it contains a mastermind-like domain typical of transcriptional co-regulators. Mutations in MAMLD1 are primarily associated with X-linked hypospadias type 2, a developmental disorder characterized by abnormal formation of the urethra in males. Research also implicates MAMLD1 mutations in other conditions such as myopathy and spermatic cord torsion, evidencing its role beyond gonadal development. |
检测原理