Overview
| 别名 | Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin; non-erythroid alpha subunit |
| 基因名 | alpha Fodrin |
| UniProt ID | Q13813 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7N9-R9-D6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 284 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Spectrin alpha, non-erythrocytic 1 (alpha Fodrin) is a filamentous cytoskeletal protein that functions as an essential scaffold for stabilizing the plasma membrane and organizing intracellular organelles. It forms heterodimers with beta spectrin subunits, which further assemble into tetramers to create a flexible meshwork. Highly expressed in cardiac muscle and various non-erythrocytic tissues, it localizes to structures such as Z-discs and the sarcolemma. The protein exhibits calcium-dependent binding properties and interacts with calmodulin and actin, suggesting a role in calcium-regulated cytoskeletal dynamics and cell adhesion. Clinically, mutations in the encoding SPTAN1 gene are a well-established cause of early infantile epileptic encephalopathy-5 (EIEE5), a severe neurological disorder characterized by developmental delay and seizures. |
检测原理