Overview
| 别名 | Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; CBF-alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; OSF-2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit |
| 基因名 | RUNX2 |
| UniProt ID | Q13950 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4S6-V5-N8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | RUNX family transcription factor 2 (RUNX2) is a nuclear protein and a member of the RUNX family characterized by a conserved Runt DNA-binding domain. It serves as the master regulator of osteoblast differentiation and skeletal morphogenesis by driving the expression of essential bone matrix genes, including Spp1, Ibsp, and Sp7. RUNX2 acts as a scaffold for various regulatory factors and modulates the cell cycle by interacting with p53 and cyclins to inhibit the proliferation of mesenchymal cells as they commit to the osteoblast lineage. It also plays a role in chondrocyte maturation and osteoclastogenesis. Mutations resulting in RUNX2 haploinsufficiency are the established cause of cleidocranial dysplasia, a skeletal disorder characterized by clavicle hypoplasia and delayed fontanelle closure. |
检测原理