Overview
| 别名 | Pro-interleukin-16 [Cleaved into: Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF] |
| 基因名 | IL16 |
| UniProt ID | Q14005 |
| 反应种属 | Human |
| 应用 | WB,IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6X2-N8-B1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 141 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | IL-16 is encoded by the IL16 gene located on chromosome 15q26.3. It is initially produced as a precursor protein (pro-IL-16) that is cleaved by caspase-3 to generate the mature, secreted form of IL-16. Both pro-IL-16 and mature IL-16 are biologically active. IL-16 functions as a chemoattractant for CD4+ T cells, monocytes, and eosinophils, and can also regulate cell growth and differentiation. Increased levels of IL-16 have been associated with various inflammatory and autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and antineutrophil cytoplasmic antibody-associated vasculitis. Genetic polymorphisms in the IL16 gene, such as rs11556218, have also been linked to an increased risk of certain cancers, as well as other conditions like diabetes and osteoarthritis. Overall, IL-16 appears to play a complex role in modulating immune and inflammatory responses, with implications for both disease pathogenesis and potential therapeutic targeting. |
检测原理