Overview
| 别名 | Enhancer of filamentation 1; hEF1; CRK-associated substrate-related protein; CAS-L; CasL; Cas scaffolding protein family member 2; CASS2; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; Renal carcinoma antigen NY-REN-12; p105) [Cleaved into: Enhancer of filamentation 1 p55] |
| 基因名 | NEDD9 |
| UniProt ID | Q14511 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1K9-U2-H9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 92 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) is a non-catalytic scaffolding protein that plays a crucial role in regulating multiple cellular processes, including cell migration, invasion, and metastasis in various cancers. It contains several functional domains, including an N-terminal SH3 domain, a substrate domain, a serine-rich region, and a C-terminal domain with a focal adhesion targeting (FAT) function and a SRC-binding motif. NEDD9 is involved in the signaling crosstalk between integrins and receptor tyrosine kinases, such as EGFR, and its overexpression has been associated with aggressive tumor behavior and poor prognosis in non-small cell lung cancer (NSCLC), breast cancer, melanoma, and other malignancies. The protein is subject to post-translational modifications, including phosphorylation and proteasomal degradation, which influence its scaffolding activity and localization. |
检测原理