Overview
| 别名 | Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3 |
| 基因名 | HLTF |
| UniProt ID | Q14527 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8G1-P3-D5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 113 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Helicase-like transcription factor (HLTF) is a multifunctional DNA translocase of the SWI/SNF family, possessing ATP-dependent helicase and E3 ubiquitin ligase activities. It contains a HIRAN domain for recognizing DNA structures, a SWI/SNF-type ATPase domain, and a RING finger domain. HLTF is critical for genome stability, functioning as the human homolog of yeast RAD5 in error-free post-replication repair. It is recruited to stalled replication forks, where it polyubiquitinates PCNA and promotes fork reversal, facilitating DNA damage tolerance. In oncology, HLTF acts as a tumor suppressor; its promoter is frequently hypermethylated in colorectal and gastric cancers, and its inactivation leads to genomic instability and altered sensitivity to DNA-damaging agents. |
检测原理