Overview
| 别名 | Inositol 1; 4; 5-trisphosphate-gated calcium channel ITPR1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Inositol 1; 4; 5 trisphosphate receptor; Inositol 1; 4; 5-trisphosphate receptor type 1; Type 1 inositol 1; 4; 5-trisphosphate receptor; Type 1 InsP3 receptor |
| 基因名 | IP3 Receptor |
| UniProt ID | Q14643 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7V3-J3-S5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 313 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Inositol 1,4,5-trisphosphate receptor type 1 (IP3 Receptor) is a large tetrameric intracellular calcium release channel primarily localized to the endoplasmic reticulum membrane. Each subunit contains a cytosolic N-terminal IP3-binding core and a C-terminal six-transmembrane channel domain that forms a calcium-selective pore. The receptor is activated by the binding of IP3, produced downstream of G-protein-coupled receptor signaling, which primes the channel for calcium-induced calcium release. This mechanism regulates critical cellular processes including synaptic plasticity, gene expression, and apoptosis. IP3 Receptor is highly expressed in cerebellar Purkinje cells and is essential for motor coordination. Pathogenic variants in the ITPR1 gene cause autosomal dominant spinocerebellar ataxias and Gillespie syndrome, characterized by cerebellar atrophy, ataxia, and developmental delay. |
检测原理