Overview
| 别名 | Rab3 GTPase-activating protein catalytic subunit; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP |
| 基因名 | RAB3GAP1 |
| UniProt ID | Q15042 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9T2-O4-J6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 110 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | RAB3 GTPase activating protein catalytic subunit 1 (RAB3GAP1) is the catalytic component of the Rab3GAP complex, which regulates small GTPases involved in vesicle trafficking. It forms a heterodimer with RAB3GAP2 and exhibits dual enzymatic activities: it acts as a GTPase-activating protein (GAP) for the Rab3 subfamily to modulate neurotransmitter and hormone exocytosis, and as a guanine nucleotide exchange factor (GEF) for RAB18. Through these roles, RAB3GAP1 maintains endoplasmic reticulum structure, lipid droplet homeostasis, and autophagy. The protein is essential for normal eye and brain development. Mutations in RAB3GAP1 are the primary cause of Warburg micro syndrome 1, a severe neurodevelopmental disorder characterized by microcephaly, microphthalmia, and corpus callosum hypoplasia. |
检测原理